The 2021–22 SIU Edwardsville Cougars men's basketball team represented Southern Illinois University Edwardsville in the 2021–22 NCAA Division I men's basketball season.

The Cougars, led by third-year head coach Brian Barone, played their home games at the First Community Arena in Edwardsville, Illinois as members of the Ohio Valley Conference (OVC).

[1] They lost in the first round of the OVC tournament to Tennessee State.

[2] In a season limited due to the ongoing COVID-19 pandemic, the Cougars finished the 2020–21 season 9–17, 7–12 in OVC play, to finish in eighth place.

[3] In the first round of the OVC tournament, they were defeated by Belmont.