A total of 110 clubs initially entered the competition, reduced from 132 in 2019–20, mainly due to more teams joining the East of Scotland League and clubs that did not retain SJFA membership after moving to the West of Scotland League.
They successfully defended their title for a second time with a 2–0 win over Yoker Athletic in the final.
The dates for each round of the 2021–22 tournament were as follows: Drawn matches proceeded direct to a penalty shootout, there was no extra time.
[3] Unlike previous seasons, all clubs—including Auchinleck Talbot, Banks O’ Dee, Cumnock Juniors, Girvan, and Irvine Meadow XI who are also taking part in the Scottish Cup—were entered into the first round draw.
The Final of the Scottish Junior Cup was played at Rugby Park, Kilmarnock on Saturday 4 June with a 4.10pm kick off.