The 2021–22 South Dakota State Jackrabbits women's basketball team represented South Dakota State University in the 2021–22 NCAA Division I women's basketball season.

The Jackrabbits, led by 22nd-year head coach Aaron Johnston, compete in the Summit League.

They played their home games in Frost Arena in Brookings, South Dakota.

South Dakota State lost in the quarterfinals in an upset to #8 seed Omaha, but still qualified for the 2021 NCAA Division I women's basketball tournament as an at-large bid.

In the 2021 NCAA tournament, the Jacks received a nine seed in the River Walk Regional and played Syracuse, to whom they lost 55–72.