The 2021–22 Seton Hall Pirates women's basketball team represented Seton Hall University during the 2021–22 NCAA Division I women's basketball season.

The Pirates, led by ninth year head coach Anthony Bozzella, played their home games in South Orange, New Jersey at the Walsh Gymnasium as members of the Big East Conference.

The Pirates finished in the middle of the Big East with a 12–8 record and lost to Villanova in the semifinals of the conference tournament.

In postseason, Seton Hall was invited to the 2022 Women's National Invitation Tournament where they won five straight games to appear in the final.

They lost in the first round of the Big East women's tournament to Creighton.