The season started on 19 November 2021 and concluded with the final on 20 March 2022.

[1][2][3] Except for the final, it was hosted behind closed doors across three venues in Goa due to the COVID-19 pandemic in India.

[7] FSDL, agreeing to the suggestions made by AIFF Executive Committee have made significant changes in players registration and foreign players number in the squad enforceable from 2021 to 2022 Indian Super League season.

[8] The changes have been made keeping in mind the AFC Club competitions regulations which follow 3+1 foreign players rule and to give more chances to domestic players in the league.

The changes made were: [49] Bold letters suggest the player was signed in the winter transfer window