The 2021 AFC Champions League qualifying play-offs were played from 7 April to 23 June 2021.
[1] A total of 15 teams competed in the qualifying play-offs to decide seven of the 40 places in the group stage of the 2021 AFC Champions League.
Extra time and penalty shoot-out were used to decide the winner if necessary.
[1][5][6] On 11 March 2021, the AFC announced that the preliminary round and play-off round matches in the East Region, which were originally scheduled to be played on 7 April and 14 April 2021, had been postponed to June/July 2021, and were played in centralised venues of their respective group stage matches.
The eight winners of the play-off round (four each from both West Region and East Region) advanced to the group stage to join the 32 direct entrants.