The 2021 Andy's Frozen Custard 335 was a NASCAR Xfinity Series race that was held on October 16, 2021, at the Texas Motor Speedway in Fort Worth, Texas.

Joe Gibbs Racing driver John Hunter Nemechek collected his first win of the season, and the second of his career.

The track measures 1.5 miles (2.4 km) around and is banked 24 degrees in the turns, and is of the oval design, where the front straightaway juts outward slightly.

A. J. Allmendinger was awarded the pole for the race as determined by competition-based formula.

Timmy Hill did not have enough points to qualify for the race.