The 2021 Cook Out 250 was a NASCAR Xfinity Series race held on April 9, 2021.

JR Motorsports driver Josh Berry, running part-time, collected his career Xfinity series win.

At 0.526 miles (0.847 km) in length, it is the shortest track in the NASCAR Xfinity Series.

Harrison Burton was awarded the pole for the race as determined by competition-based formula.

[3] Jordan Anderson, Ronnie Bassett Jr., and Andy Lally did not have enough points to qualify for the race.