The 2021 Drive for the Cure 250 was a NASCAR Xfinity Series race that was held on October 9, 2021, at the Charlotte Motor Speedway in Concord, North Carolina.

The course is 2.28 miles (3.67 km) in length and features 17 turns, utilizing the infield road course and portions of the oval track.

During July 2018 tests on the road course, concerns were raised over drivers "cheating" the backstretch chicane on the course.

In the summer of 2019, the bus stop on the backstretch was changed and deepened, becoming a permanent part of the circuit, compared to the previous year where it was improvised.

If a driver fails to legally make the backstretch bus stop, the driver must skip the frontstretch chicane and make a complete stop by the dotted line on the exit before being allowed to continue.