The 2021 Arkansas State Red Wolves football team represented Arkansas State University in the 2021 NCAA Division I FBS football season.

The Red Wolves played their home games at Centennial Bank Stadium in Jonesboro, Arkansas, and competed in the West Division of the Sun Belt Conference.

[1] The team announced Rob Harley as their new defensive coordinator shortly after Jones' arrival.

The Red Wolves were picked to finish second in the West Division and fourth overall in the conference.

[9] Roster Last update: 6 July 2021 The 2021 schedule consists of 6 home and 6 away games in the regular season.