The Mountaineers were led by second-year head coach Shawn Clark.

Appalachian State played their home games at Kidd Brewer Stadium on the school's Boone, North Carolina, campus, and competed as a member of the East Division of the Sun Belt Conference.

Roster Last update: April 25, 2021 The 2021 schedule had 6 home, 5 away, and one neutral game in the regular season.

The Mountaineers hosted Sun Belt foes Coastal Carolina, Louisiana–Monroe, South Alabama, and Georgia Southern.

Appalachian State hosted two of the four non-conference opponents at Kidd Brewer Stadium, Elon, from NCAA Division I FCS and Marshall of the Conference USA, traveled to Miami (FL) of the ACC, and played a neutral site game against East Carolina of The American at Bank of America Stadium.