The 2021 South Alabama Jaguars football team represented the University of South Alabama during the 2021 NCAA Division I FBS football season.

The Jaguars played their home games at Hancock Whitney Stadium in Mobile, Alabama.

Prior to the season, South Alabama saw a near complete overhaul of its coaching staff, including Kane Wommack taking over as head coach, Major Applewhite taking over as offensive coordinator, and Corey Batoon taking over as defensive coordinator.

Roster Last update: 9 July 2021 The 2021 schedule consists of 6 home and 6 away games in the regular season.

South Alabama will play host to Sun Belt foes Louisiana, Georgia Southern, Arkansas State, and Coastal Carolina.