Incumbent Democratic Mayor Miro Weinberger defeated Progressive nominee Max Tracy, independent Ali Dieng, and various other minor candidates.

Tim Ashe, who unsuccessfully sought the Democratic nomination in 2012, declined to run in 2021.

[6][7][8] Brian Pine, who served on the city council in the 1990s and since 2018, announced that he would seek the Progressive mayoral nomination.

[9] Max Tracy, the president of the city council, announced that he would seek the Progressive mayoral nomination.

[12][13][14] Haik Bedrosian, who served on the city council in 1990s and had run for mayor in 1991, ran as an independent.

Despite losing the mayoral election the Vermont Progressive Party retained control of the city council with six out of twelve seats and saw multiple ballot initiatives endorsed by them win.