[1] The winners of the tournament, CF Montréal, were awarded the Voyageurs Cup and earned a berth in the 2022 CONCACAF Champions League.
For the first time in the Canadian Championship, each tie was played as a single-leg fixture.
CF Montréal, Forge FC, and Toronto FC entered the tournament in the quarter-finals due to their placements in the 2019 and 2020 editions of the competition.
A.S. Blainville and Master's FA were originally supposed to participate in the 2020 edition of the competition, as they won the 2019 editions of the Première ligue de soccer du Québec and League1 Ontario, respectively.
As the format of the 2020 edition was revised, their participation was postponed to the 2021 tournament.