The winners of the 2022 CONCACAF Caribbean Club Shield, as long as they fulfill the CONCACAF Regional Club Licensing criteria, play against the fourth place team of the 2022 CONCACAF Caribbean Club Championship in a playoff match to determine the final Caribbean spot to the 2022 CONCACAF League.

[2][3] In the final, Bayamon FC defeated Inter Moengotapoe, 2–1, after extra-time with a game-winning goal scored by Jordi Ranera in the 121st minute, to win their first title.

Among the 31 CFU member associations, 27 of them were classified as non-professional leagues and each may enter one team in the CONCACAF Caribbean Club Shield.

The draw for the group stage was held on 3 February 2022, 11:00 EST (UTC−5), at the CONCACAF Headquarters in Miami, United States.

The team from the host association Puerto Rico, Bayamon FC, were allocated to position A1, while the remaining 12 teams were drawn into the other group positions without any seeding.