Due to COVID-19 cross-border restrictions imposed by the Canadian government, Toronto FC, along with the two other Canadian MLS teams (CF Montréal and Vancouver Whitecaps FC), played in the United States at the beginning of the season while also sharing stadiums with other American MLS teams.

[2][1] On July 14, MLS announced that Toronto FC were allowed to play two home matches on July 17 and 21, although they continued to work with the Canadian Government regarding plans on future home matches.

[3][4] Outside of the MLS season, Toronto finished as the runners-up of the 2021 Canadian Championship after losing the final to rivals CF Montréal 1–0.

They traded an International roster spot for the 2021 season to FC Dallas in exchange for $225,000 of General Allocation Money (GAM) on April 20, 2021.

[7] They traded another international roster spot to Orlando City SC in exchange for $200,000 of General Allocation Money (GAM) on April 27, 2021.