For the 75th anniversary of the team's founding in 1946, the Browns introduced a commemorative logo in January to use for the season.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve The Browns' 2021 schedule was announced on May 12.

[12] DE Myles Garrett set a franchise record with 4.5 sacks[12] and was named AFC Defensive Player of the Week.

The Browns became the first team in NFL history to lose a game despite scoring 40+ points and having no turnovers.

This loss ended a 6-game winning streak over NFC opponents and marked the first time the Browns lost consecutive games under head coach Kevin Stefanski.

Starting quarterback Baker Mayfield left the game after aggravating a shoulder injury he suffered earlier in the season.

Johnson, who was making his first career start in place of injured RBs Nick Chubb and Kareem Hunt, had 22 carries for 146 yards and a touchdown, including several key runs to run out the clock and preserve the win.

After 25 Browns players and three coaches, including head coach Kevin Stefanski, tested positive for COVID-19 in the week leading up to the game, the game was postponed from its original date of December 18 to December 20.

This game marked the first time in franchise history that the Browns played on Christmas Day.

On January 2, Cincinnati defeated Kansas City to clinch the AFC North title.

With the Los Angeles Chargers’ win over Denver later that day, the Browns were eliminated from playoff contention.

The following Browns were awarded for their performances during the season: On December 20, it was announced that G Joel Bitonio, RB Nick Chubb, DE Myles Garrett, G Wyatt Teller, and CB Denzel Ward were named to the AFC Pro Bowl roster, with Bitonio and Garrett named as starters.

This marks the fourth Pro Bowl selection for Bitonio, the third for Chubb and Garrett, the second for Ward, and the first for Teller.