[5] They would then upset the #1 seeded Green Bay Packers 13–10 in the divisional round, thus advancing to the NFC Championship for the second time in 3 years.

In Trey Lance's first NFL start the 49ers lose a closer than expected game and fall to 2–3 on the season.

Despite the Cardinals having an injury–depleted roster, the 49ers suffer an embarrassing loss to former 49ers QB Colt McCoy and fall to 3–5 on the season.

The 49ers bounced back against their interstate rivals, defeating them for the 5th consecutive time and bringing their record up to 4–5 for the season.

Late heroics and extra time was needed in this regular season classic, Aiyuk and the 49ers leaped to 7–6.

Despite taking a 10–0 lead, the 49ers could not overcome the Titans, who outscored them 20–7 to drop them to 8–7, making their playoff chances looking slim.

In overtime, Robbie Gould put the 49ers ahead and Ambry Thomas officially punched the 49ers ticket to the playoffs when he picked off Matthew Stafford, the 49ers would finish the regular season at 10–7.

This included five sacks, holding the Cowboys to just 77 yards rushing, and one interception, which led to a 49ers touchdown on the next play.

The 49ers' Cinderella run continued as they traveled to Lambeau Field and pulled off the upset in a 13–10 win over the heavily favored Green Bay Packers.

The Packers started the game with a six-yard touchdown run by AJ Dillion to take a 7–0 lead.

For the rest of the game, the 49ers defense only surrendered three more points, aided by five sacks, a fumble recovery, and only giving up 263 total yards of offense to the Packers.

The 49ers special teams was pivotal, as they blocked a Packers field goal right before halftime, returned a blocked punt for a game-tying touchdown late in the game, and finally, converted a game-winning field goal by kicker Robbie Gould as time expired, the last of which advanced them to their second NFC Championship in the last three seasons and the 17th NFC Championship overall as a franchise.

The two teams traded punts before Rams quarterback Matthew Stafford drove the offense to the 49ers' 3-yard line before throwing a drive-ending interception to Jimmie Ward.

However, San Francisco struck right back with Jimmy Garoppolo hitting Deebo Samuel for a 44-yard touchdown to tie the game up at 7.

On the Rams' ensuing drive, long passes by Stafford led to Kupp's second touchdown of the game from 11 yards out to cut the deficit to 17–14 with thirteen minutes left.

With just under two minutes remaining, the 49ers' offense trotted out on the field in an attempt to make a desperate last-minute drive to tie the game.

After an incompletion on first down, Garoppolo completed a pass to Jauan Jennings, but was tackled immediately by the Rams' Travin Howard to bring up a 3rd-and-13 on the 49ers' 22-yard line.