The ninth edition of Dwars door Vlaanderen's women's race was held on Wednesday 31 April 2021.

The race started and finished in Waregem, and it was won by Annemiek van Vleuten (Movistar Team) ahead of Katarzyna Niewiadoma (Canyon–SRAM) in a sprint of two.

Alexis Ryan (Canyon–SRAM) won the bunch sprint for third place.

[1] Eight UCI Women's WorldTeams and twenty UCI Women's Continental Teams competed in the race.

UCI Women's WorldTeams UCI Women's Continental Teams This cycling race article related to Belgian cycling is a stub.