The 2021 East Carolina Pirates baseball team represented East Carolina University during the 2021 NCAA Division I baseball season.

The Pirates played their home games at Clark–LeClair Stadium as a member of the American Athletic Conference They were led by head coach Cliff Godwin, in his seventh year as head coach.

The 2020 East Carolina Pirates baseball team notched a 13–4 (0–0) regular-season record.

The season prematurely ended on March 12, 2020, due to concerns over the COVID-19 pandemic.