The 2021 Eschborn–Frankfurt was a road cycling one-day race that took place on 19 September 2021 in the Frankfurt Rhein-Main metro area in southwest Germany.

[2] The race returned to the UCI World Tour calendar after the 2020 edition was cancelled due to the COVID-19 pandemic.

[3] Traditionally, the race takes place on 1 May, the Labour Day holiday in Germany, but it was postponed due to COVID-19 precautions.

After entering Frankfurt and riding around most of the finishing circuit, the race traveled northwest through Oberursel into the Taunus to take on several hills.

From there, the race passed through the start line in Eschborn again before finishing with almost three complete laps of a 5.5-kilometre (3.4 mi) technical circuit in Frankfurt near the Main River.