The 2021 Esiliiga was the 31st season of the Esiliiga, the second-highest Estonian league for association football clubs, since its establishment in 1992.
The season began on 4 March 2021 and concluded on 21 November 2021.
Defending champions Maardu Linnameeskond won their second Esiliiga title.
Alliance won 4–1 on aggregate.
Ats Purje was named Esiliiga Player of the Year.