The 2021 Florida State Seminoles baseball team represented Florida State University in the 2021 NCAA Division I baseball season.

The Seminoles played their home games at Mike Martin Field at Dick Howser Stadium as a member of the Atlantic Coast Conference.

They were led by head baseball coach Mike Martin, Jr. in his second year as head coach.

In 2020, the Seminoles finished with an overall record of 12-5, 1-2 in ACC Conference play, including a win against then-unbeaten rival Florida, before the season was cancelled due to the COVID-19 pandemic.