The 2021 Virginia Cavaliers baseball team represented the University of Virginia during the 2021 NCAA Division I baseball season.

The Cavaliers played their home games at Davenport Field as a member of the Atlantic Coast Conference.

They were led by head coach Brian O'Connor, in his 18th season at Virginia.

Virginia qualified for the College World Series for the first time since the 2015 national championship season, where they finished 1–2.

^ Collegiate Baseball ranked 40 teams in their preseason poll, but only ranked 30 teams weekly during the season.† NCBWA ranks 35 teams in their preseason poll, but only ranks 30 teams weekly during the season.