The 2021 Iowa State Cyclones football team represented Iowa State University during the 2021 NCAA Division I FBS football season.

The Cyclones played their home games at the Jack Trice Stadium in Ames, Iowa, and competed in the Big 12 Conference.

The team was coached by sixth-year head coach Matt Campbell, who received an extension the previous offseason.

Iowa State began the season ranked seventh in the AP poll, the highest preseason ranking ever achieved by the Cyclones.

Source:[2] at Jack Trice Stadium • Ames, IA at Jack Trice Stadium • Ames, IA at Allegiant Stadium • Las Vegas, NV at McLane Stadium • Waco, TX at Jack Trice Stadium • Ames, IA at Bill Snyder Family Stadium • Manhattan, KS at Jack Trice Stadium • Ames, IA at Milan Puskar Stadium • Morgantown, WV at Jack Trice Stadium • Ames, IA at Jones AT&T Stadium • Lubbock, TX at Memorial Stadium • Norman, OK at Jack Trice Stadium • Ames, IA at Camping World Stadium • Orlando, FL All totals via Sports Media Watch.