The 2021 Los Cabos Open (also known as the Mifel Open for sponsorship reasons) was an ATP tennis tournament played on outdoor hard court.

It was the 5th edition of the tournament, and part of the ATP Tour 250 series of the 2021 ATP Tour.

It took place in Los Cabos, Mexico from 19 July through 25 July 2021.

[1] *per team The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: