The Cardinals played their home games at Jim Patterson Stadium as a member of the Atlantic Coast Conference.

They were led by head coach Dan McDonnell, in his 15th season at Louisville.

With a record of 28-22, the Cardinals missed the NCAA Tournament for the first time since 2011.

[2] The 2020 Louisville Cardinals baseball team notched a 13–4 (2–1) regular season record.

The season prematurely ended on March 12, 2020, due to concerns over the COVID-19 pandemic.