The team was led during the regular season by Lincoln Riley, in his fifth and final year as head coach.

Sources: Outgoing The Oklahoma Sooners lost seventeen players via transfer portal for the 2021 season.

Incoming The Oklahoma Sooners add nine players via transfer portal from the 2020 season.

The Sooners hosted 2 non-conference games against Western Carolina and Nebraska and was originally scheduled to travel to Tulane, but the effects of Hurricane Ida forced the game to be played in Oklahoma with Tulane still being the home team.

[21] Quarterback Running back Wide receiver Tight end Long snapper Offensive line Defensive line Linebacker Defensive back Placekicker Punter