[1] It was a tri-nation series between Nepal, Oman and the United States cricket teams, with the matches played as One Day International (ODI) fixtures.

[5] In January 2021, USA Cricket named a 44-man squad to begin training in Texas ahead of the series.

[6][7] The following month, the Cricket Association of Nepal named a 32-man preliminary squad to begin training for the series.

[13] The United States named Kyle Phillip as a travelling reserve player for the tour,[17] and later named Sanjay Krishnamurthi as another reserve player.

[19] Nepal's Dipendra Singh Airee was also ruled out of the series, after suffering an ankle injury.