The 2021 Presbyterian Blue Hose football team represented Presbyterian College in the 2021 NCAA Division I FCS football season as a member of the Pioneer Football League (PFL).

Led by first-year head coach Kevin Kelley, the Blue Hose played home games at Bailey Memorial Stadium.

[1] In the opening game of the season against St. Andrews, Presbyterian quarterback Ren Hefley threw for an FCS single-game record 10 touchdowns in the 84–43 win.

[2] He completed 38 of 50 pass attempts and threw for 538 yards.

[2] Blue Hose backup quarterback Tyler Huff added two touchdown passes to set a new Division I team record (for both FCS and FBS) of 12.