The 2021 St. Thomas Tommies football team represented the University of St. Thomas in Saint Paul, Minnesota as a member of the Pioneer Football League (PFL) during the 2021 NCAA Division I FCS football season.
Led by 13th-year head coach Glenn Caruso, the Tommies compiled an overall record of 7–3 with a mark of 6–2 in conference play, tying for third place in the PFL.
St. Thomas played home games at O'Shaughnessy Stadium in Saint Paul, Minnesota.
[1] This was the St. Thomas's first season competing at the NCAA Division I Football Championship Subdivision (FCS) level after transitioning from NCAA Division III.
The 2020 season was initially postponed to the spring of 2021 and then canceled because of the COVID-19 pandemic.