The Padres entered the 2021 season expecting to contend for the World Series, having made several major acquisitions in the offseason, and held a playoff position in the Wild Card standings from April to late August.

The Padres were eliminated from playoff contention on September 25, and finished the 2021 season with a very disappointing record of 79–83.

The no-hitter also broke a streak of having gone 8,205 games without throwing one, a major league record.

Source: MLB Standings Grid – 2021 Updated with the results of all games through October 3, 2021.

July 25: Tucupita Marcano, Jack Suwinski, & Michell Miliano to the Pittsburgh Pirates in exchange for 2B Adam Frazier July 30: Mason Thompson & Jordy Barley to the Washington Nationals in exchange for RP Daniel Hudson July 30: Anderson Espinoza to the Chicago Cubs for OF Jake Marisnick Infielders Outfielders Coaches Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; BB = Walks; AVG = Batting average; SLG = Slugging average Source:[1] Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Runs allowed; ER = Earned runs allowed; BB = Walks allowed; SO = Strikeouts Source:[2]