The 2021 McNeese State Cowgirls softball team represented McNeese State University during the 2021 NCAA Division I softball season.

The Cowgirls played their home games at Joe Miller Field at Cowgirl Diamond and were led by fifth year head coach James Landreneau.

The Southland Conference Coaches Poll was released on February 5, 2021.

McNeese State was picked to finish second in the Southland Conference with 217 votes and four first place votes.

[2] [3] [4] Pitchers Outfielders Utilities Catchers Infielders *Rankings are based on the team's current ranking in the NFCA/USA Softball poll.