The 2021 season for the Team BikeExchange team was the team's 10th season in existence, all of which have been as a UCI WorldTeam.

[3] Ahead of the season, Scott Sports, one of the co-title sponsors from the previous season, was dropped as the team switched to Bianchi Bicycles, though Bianchi did not become a title sponsor.

[1] Additionally, Mitchelton Wines, a brand owned by team owner Gerry Ryan, was also dropped from co-title sponsor after three years.

It was replaced by Australian cycling retailer BikeExchange, another Ryan brand which had previously been co-title sponsor for the 2016 season and which became the sole title sponsor.

[4]