2021 USL League One season

The regular season began on April 10 and ended on October 30, 2021.

North Carolina FC joined the league for this season, after leaving the USL Championship in what the team called a "strategic move" to enhance its youth development pathway.

[2] Greenville Triumph SC were the defending champions on both regular season and playoffs.

The 2021 USL League One Playoffs (branded as the 2021 USL League One Playoffs presented by TwinSpires for sponsorship reasons) was the post-season championship of the USL League One season.

Championship Game MVP: Damià Viader (Union Omaha) (H) – Home team(A) – Away team