The 2021 Western Kentucky Hilltoppers football team represented Western Kentucky University during the 2021 NCAA Division I FBS football season.

The Hilltoppers played their home games at Houchens Industries–L.

T. Smith Stadium in Bowling Green, Kentucky, and competed in the East Division of Conference USA (CUSA).

Western Kentucky announced its 2021 football schedule on January 27, 2021.

[1][2] The 2021 schedule consists of 6 home and 6 away games in the regular season.