After losing in the 2022 Clausura final, Pachuca won the 2022 Apertura championship, defeating Toluca 8–2 over the two legs.

[1] After an aggregate 2–2 score, Pachuca advanced from the quarter-finals by virtue of finishing ahead of Tigres during the regular phase.

[2] Players and squad numbers last updated on 4 July 2022.

[3]Note: Flags indicate national team as has been defined under FIFA eligibility rules.

[9] Pachuca will enter the Leagues Cup in the Round of 32