The top two teams from each group advanced to the knockout stage to compete in a single-elimination tournament.
There were 32 matches in the knockout stage, including a third-place play-off played between the two losing teams of the semi-finals.
The top two placed teams from each of the fifteen groups qualified for the knockout stage, joining Los Angeles FC and Pachuca, who received byes to this round.
The tournament bracket is shown below, with bold denoting the winners of each match.
The winner of the third place match qualified for the first round of the 2024 CONCACAF Champions Cup.