[2] For the first time in the history of the competition, all MLS and Liga MX teams (47 total) competed in the tournament, with both leagues taking a pause in their respective seasons to participate.

The MLS Cup 2022 winners (Los Angeles FC) and the 2022 Clausura or 2022 Apertura champions with the highest aggregate points accumulated across 2022 (Pachuca) qualified automatically for the round of 32.

[1][4][5] Matches disrupted by inclement weather, including thunderstorms, were delayed or postponed to another date to resume at the time of the stoppage.

[6] The top two teams in each group advanced to the round of 32, joining the MLS Cup winners and highest-ranked Liga MX champion.

In the knockout stage, if the scores were equal at the end of regulation time, a penalty shoot-out was used to determine the winners.

Matches between two Liga MX teams were hosted at a neutral venue appointed by the Organizing Committee from a predetermined list.

The official song of the tournament was "Tiki Taka Toco", sung in Spanish by California-based Mexicana group Fuerza Regida.

A short instrumental version of the song is used for match broadcasts on MLS Season Pass as well as advertisements and stadium announcements.

For example, Nicolás Larcamón, coach of Club León stated: "there is a benefit for the MLS teams, on their field, in their environment, in their climate.

[18] The Mexican (and LAFC) player Carlos Vela declared: "Obviously, for me, the fairest thing is we should also had games in Mexico, that it shouldn't be all playing in the United States, so that everyone could had a little bit of playing away, at home, and being a little more even" he also added: “Not only does (being local) benefit, the Mexican team has to be away from their home and their families for a long time and it is not fair.

[16][20] “It’ll be our fifth game (traveling), while LA(FC) will be home with their players eating dinner with their families every night, going to the movies, resting,” he stated.