In addition to the domestic league, Espérance de Tunis participated in this season's editions of the Tunisian Cup and the CAF Champions League.
Espérance de Tunis was not scheduled to play any matches between 9 November and 10 December as Mohamed Ali Ben Romdhane, Ghailene Chaalali and Yassine Meriah participated with Tunisia at 2022 FIFA World Cup in Qatar.
Despite finishing second in the league and advancing to the Champions League semi-finals, Espérance de Tunis went trophyless and lost the Tunisian Ligue Professionnelle 1 for the first time since the 2015–16 season.
Note: Flags indicate national team as has been defined under FIFA eligibility rules.
Source: Competitive matches NB: As Group A winners, Espérance de Tunis were added 4 points in the playoff that were not counted in this summary.