It was their 67th consecutive season in the top flight of Tunisian football.
On the domestic front, Espérance de Tunis delivered two trophies out of possible four, winning the Ligue 1, in the last round after a late 2–1 win against US Ben Guerdane, and the 2020–21 Tunisian Super Cup, but they left the Tunisian Cup against CS M'saken after a 1–1 draw after 120 minutes and a 6–5 loss on penalties.
On the continental front, Espérance de Tunis left the Champions League from the quarter-finals after a surprise loss to ES Sétif with a score of 1–0 on aggregate.
Note: Flags indicate national team as has been defined under FIFA eligibility rules.
Win Draw Loss Source: Competitive matches NB: As Group A winners, Espérance were added 3 points that are not counted in this summary.