The season began on September 1, 2022, and ended with the 2022 Pac-12 Championship Game on December 2, 2022, at Allegiant Stadium in Paradise, Nevada.

On May 18, 2022, the NCAA Division I Council approved a rule change that gave conferences complete freedom in choosing the participants in their championship games.

[1] On that same day, the Pac-12 announced that effective immediately, the championship game would feature the top two teams in the conference standings.

[3] Oregon, Utah, and Washington finished the regular season in a 3-way tie for 2nd place.

The Utah Utes defeated Oregon Ducks 38–10 in the Pac-12 Football Championship Game.

[9] The teams and representatives in respective order were as follows: The preseason polls was released on July 28, 2022.

Below are the results of the media poll with total points received next to each school and first-place votes in parentheses.

All Pac–12 Honorable Mention (received votes from four or more members of the media): There was three coaching changes before the 2022 season.

[47] On September 18 following their loss to Eastern Michigan, Arizona State and coach Herm Edwards agreed to part ways.

† denotes Homecoming game Rankings reflect those of the AP poll for weeks 1 through 9.

Starting in 2022, the two teams with the highest conference winning percentage will face off in the championship game.

After a 48-45 victory over their home town rival, USC clinched the first spot in the conference title game.

The Pac-12 champion are also eligible for the College Football Playoff if they're among the top four teams in the final CFP ranking.

Notes: Honorable mentions Currently, the NCAA compiles consensus all-America teams in the sports of Division I-FBS football and Division I men's basketball using a point system computed from All-America teams named by coaches associations or media sources.