The 2022 Big Machine Music City Grand Prix was the fourteenth round of the 2022 IndyCar season.

On lap 3, Colton Herta bumped the wall while attempting to pass Dalton Kellett on the outside of turn 4.

On lap 8, shortly after pitting, the rear wheels of Alexander Rossi's car locked going into turn 10.

Pole sitter Scott McLaughlin had led the race to this point, but when he and many other drivers pitted, it gave the lead to Palou.

This led to Graham Rahal hitting the back of Pato O'Ward who in turn tapped Will Power.

Further behind them, Callum Ilott stalled while Dalton Kellett and Simona De Silvestro received damage, ending their races.

Alexander Rossi and Callum Ilott ended up in the turn 9 runoff area but were able to continue.

Álex Palou had continued to lead the race until this point but pitted during the ensuing caution period.

On lap 64, Kyle Kirkwood attempted a late pass of David Malukas on the inside of turn 9.