[1] Olimpia defeated Alajuelense in the final to win their second CONCACAF League title.

As winners, they and the next best five teams qualified for the 2023 CONCACAF Champions League.

[2][3] Comunicaciones were the title holders, but were eliminated by Diriangén in the Round of 16.

All of the leagues of Central America employ a split season with two tournaments in one season, so the following teams qualified for the CONCACAF League: If teams from any Central American associations were excluded, they would be replaced by teams from other Central American associations, with the associations chosen based on results from previous CONCACAF League and CONCACAF Champions League tournaments.

Since 2018, the CONCACAF Caribbean Club Championship is open to teams from professional leagues, where they can qualify as champions or runners-up of their respective association's league in the previous season, while the CONCACAF Caribbean Club Shield is open to teams from non-professional leagues, where they can qualify as champions of their respective association's league in the previous season.

The six preliminary round winners, whose identity was not known at the time of the draw, were placed in Pot 4 and could be drawn into the same tie with another team from the same association.

The seeding of teams was based on the CONCACAF Club Index.

To determine the total points awarded to a slot in any single edition of the CONCACAF League or CONCACAF Champions League, CONCACAF uses the following formula: Teams qualified for the CONCACAF League based on criteria set by their association (e.g., tournament champions, runners-up, cup champions), resulting in an assigned slot (e.g., CRC1, CRC2) for each team.

Olimpia won 7–1 on aggregate Real España won 4–2 on aggregate Alajuelense won 3–0 on aggregate In the semi-finals, the matchups were determined as follows: The semi-finalists in each tie which had the better performance in previous rounds (excluding preliminary round) hosted the second leg.

Based on the ranking, the top six teams, i.e., champions, runners-up, both losing semi-finalists, and best two losing quarter-finalists, qualify for the 2023 CONCACAF Champions League.