León won their first title, defeating Los Angeles FC of MLS in the final 3–1 on aggregate.

As winners, they earned the right to play in the 2023 FIFA Club World Cup in Saudi Arabia as well as the 2025 FIFA Club World Cup in the United States alongside the winners from 2021 to 2024.

[3] In the following table, the number of appearances, last appearance, and previous best result count only those in the CONCACAF Champions League era starting from 2008–09 (not counting those in the era of the Champions' Cup from 1962 to 2008).

The draw took take place in Miami, Florida, United States on 7 November 2022.

[5] The CONCACAF Club Index, instead of ranking each team, was based on the on-field performance of the teams that occupied the respective qualifying slots in the previous five editions of the CONCACAF Champions League.

To determine the total points awarded to a slot in any single edition of the CONCACAF Champions League, CONCACAF used the following formula: The slots were assigned by the following rules:[6] The 16 teams were distributed in the pots as follows:[7] Each tie, including the final, was played over two legs, with each team playing on a home-and-away basis.

In the semi-finals, the matchups were determined as follows: The semi-finalists in each tie which had the better performance across all previous rounds hosted the second leg.