The Bearcats, members of the American Athletic Conference, played their home games at Nippert Stadium in Cincinnati, Ohio.

[4] On January 5, 2022, Brian Mason who had been with Cincinnati for the previous 5 seasons, including the last four as special teams coordinator was hired by Notre Dame in the same role.

[9] On January 18, 2022, The Athletic reported that Kerry Coombs was being hired as the new cornerbacks coach and special teams coordinator.

[10] Coombs joins Cincinnati after serving most recently as defensive coordinator at Ohio State the previous two seasons.

[12] On February 21, 2022, Cincinnati announced it has promoted offensive graduate assistant Nate Letton to tight ends coach.

[13] On March 3, 2022, it was reported that Greg Scruggs accepted an assistant defensive line coach position with the New York Jets.