The Keg of Nails is a traveling trophy continuously awarded to the winner of the American college football rivalry game between the Cincinnati Bearcats and Louisville Cardinals.

It is believed to be the oldest rivalry for the Louisville football team and the second-oldest for Cincinnati, only behind the Victory Bell with the Miami RedHawks.

The match-up gained more significance with the growth of both programs into the 2000s, primarily with the success under coaches John L. Smith and Bobby Petrino for Louisville and Mark Dantonio, Brian Kelly, and Butch Jones for Cincinnati.

The exchange is believed to have been initiated by fraternity chapters on the UC and U of L campuses, signifying that the winning players in the game were "tough as nails."

The Bearcats and QB Gino Guidugli would overcome a 28-7 second quarter deficit and the team was ahead 40–35 with 2:20 remaining in the game.

7 Cardinals led by head coach Bobby Petrino were able to score twice at the end of the half, including on a 1-yard pass by quarterback Brian Brohm, to take a 13–10 lead to halftime.

The former starter, replaced by Pike after breaking his leg, Dustin Grutza entered the game and led the game-winning, seventy-two-yard drive for the Bearcats to win 28–20.