Incumbent Democratic governor Jared Polis won re-election to a second term, defeating Republican University of Colorado regent Heidi Ganahl in a landslide.

Outside the Denver-Boulder-Fort Collins region, Polis also won a long row of counties along the Rocky Mountains from Routt in the north to La Plata in the south, which contains a number of liberal leaning ski resort towns like Telluride, Aspen, and Steamboat Springs.

In Southern Colorado, a region historically known for coal mining, and home to a sizable Hispanic population, Polis managed to halt the decline in support for Democrats that had been taking place here since the mid-2010s in both state and federal races.

Polis also won the relatively conservative city of Colorado Springs, the first Democrat to do so in recent history, along with greatly increasing his vote share in conservative-leaning urban counties compared to 2018.

During her campaign, she highlighted her opposition to abortion (at odds with most Colorado voters), utilized incendiary right-wing rhetoric in regards to several social and cultural issues, and courted figures involved with pushing conspiracy theories about elections.