Republicans gained one seat in the U.S. House delegation, taking the vast western 3rd congressional district following the retirement of 13-term Democratic congressman Ron Kind.

Incumbent Republican Ron Johnson won a third six-year term, defeating the Democratic nominee, lieutenant governor Mandela Barnes.

[4]: 14–19  Seven of the eight incumbents ran for and won re-election — Bryan Steil (WI-01), Mark Pocan (WI-02), Gwen Moore (WI-04), Scott Fitzgerald (WI-05), Glenn Grothman (WI-06), Tom Tiffany (WI-07), and Mike Gallagher (WI-08).

In the Republican primary, Michels defeated former lieutenant governor Rebecca Kleefisch, state representative Timothy Ramthun, and former police officer Adam J. Fischer.

Incumbent Democratic lieutenant governor Mandela Barnes, first elected in 2018, did not run for re-election—he instead ran for United States Senate.

[7] State representative Sara Rodriguez won the Democratic nomination and was elected as a ticket with Tony Evers.

Other candidates in the Democratic primary included Peng Her, the CEO of Hmong Institute, and state representative David Bowen (Wisconsin politician).

[8] State senator Lena Taylor initially declared an intention to run for the office, but dropped out in December 2021, six months before the filing deadline.

[11][4]: 5  He defeated the Republican nominee, Fond du Lac County district attorney Eric Toney.

[12][13][14] Toney defeated former state representative Adam Jarchow and attorney Karen Mueller, from Chippewa Falls, in the Republican primary.

Other candidates in the Democratic primary included West Allis city councilmember Angelito Tenorio and radiologist Gillian Battino.

[18] Former state treasurer Dawn Marie Sass also circulated nomination papers but missed the filing deadline.