2022 was Dundalk's 14th consecutive season in the top tier of Irish football, their 87th in all, and their 96th in the League of Ireland.

[1] Stephen O'Donnell was the club's new head coach going into the new term, having replaced Vinny Perth in the close season.

[2] Dundalk moved into third position after the round 15 victory over Bohemians and remained in the top three—the automatic European qualification positions—for the remainder of the season.

[3] A home victory over Bohemians in round 35 guaranteed third place and qualification for the 2023–24 UEFA Europa Conference League.

For the round 12 home fixture against Shelbourne, the team wore a specially commissioned shirt in aid of the Motor Neurone Disease charity, 'Watch Your Back'.